A protein domain is a part of protein sequence and structure that can evolve , function, and exist independently of the rest of the protein chain.

This category includes articles about structural domains that can be found in families of evolutionary related proteins , as defined for example in Pfam or SCOP databases.

The EMBO Journal (1998) 17, 4511?4526, doi:10.1093/emboj/17.15.4511: Protein domains and conformational changes in the activation of RepA, a DNA replication initiator

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In the framework of the PROSITE project, we are constructing generalized profiles in order to describe local homology regions in proteins and make them searchable.